Immunodeficient mice are specialized laboratory models that lack specific components of their immune system, making them invaluable for studying human diseases and testing therapeutic interventions. These mice can be readily applied for PK/PD assays, reconstitution of a humane immune system, CDX/PDX model construction, disease research, drug efficacy evaluation and more.
foxN1 mutant
Non-obese diabetes(NOD) background
prkdc mutant
NOD background
• Impaired macrophage functions
• Impaired innate immunity
IL2rg(CD132) null mutant
• Lack receptors of important immune cytokines
• NK cell function lost (IL-15 signaling impairment)
prkdc mutant
• Lack T & B cells
• Display severe combined immunodeficiency
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