U-GEMMs

Humanized Knockins

The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.

Mice
Strain Name:C57BL/6Smoc-Tslptm2(hTSLP)Il17rtm1(hIL17R)/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-200269
Mice
Strain Name:C57BL/6Smoc-Httem1(hHTTQ145)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-234514
Mice
Strain Name:C57BL/6Smoc-Ttrtm1(hTTR)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-225087
Mice
Strain Name:C57BL/6Smoc-Ttrtm(hTTR-V50M)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-220587
Mice
Strain Name:C57BL/6Smoc-Tnfsf12/Tnfsf13tm1(hTNFSF12/hTNFSF13)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-234421
Mice
Strain Name:C57BL/6Smoc-Ugt1a1tm1(hUGT1A1)Smoc
Strain State:Developing | Cat. NO.:NM-HU-232902
Mice
Strain Name:C57BL/6Smoc-Uhrf1em1(hUHRF1)Smoc
Strain State:Developing | Cat. NO.:NM-HU-240157
Mice
Strain Name:huHSC-(NMG)
Strain State:Repository Live | Cat. NO.:NM-NSG-017
Research Application:Infectious disease; Gene therapy; Cancer; Drug targets without cross-reactivity; Immunogenicity study
Mice
Strain Name:huPBMC-(NMG)
Strain State:Repository Live | Cat. NO.:NM-NSG-015
Research Application:Infectious disease; Gene therapy;Hematopoiesis; Drug targets without cross-reactivity; Immunogenicity study
Mice
Strain Name:C57BL/6Smoc-Vegfatm1(hVEGFA)/Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-2000028
Research Application:Immunotherapy,drug screening
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