U-GEMMs

Humanized Knockins

The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.

Mice
Strain Name:C57BL/6Smoc-Itgamem1(IRES-hCD89-WPRE-polyA)tm1(hIGHA1)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-210412
Mice
Strain Name:C57BL/6Smoc-Itgamem1(IRES-hCD89-WPRE-polyA)Masp2em1(hMASP2)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-232115
Mice
Strain Name:C57BL/6Smoc-Ldlrem1Glp1rem2(hGLP1R)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-233975
Mice
Strain Name:NOD-PrkdcscidIl2rgem1Fcgrtem1(B2m-FCGRT)Smoc
Strain State:Repository Live | Cat. NO.:NM-NSG-018
Research Application:Antibody drug metabolism; drug screening
Mice
Strain Name:C57BL/6Smoc-Mefvem1(hMEFV-V726A)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-KI-200221
Disease Connection:familial Mediterranean fever
Mice
Strain Name:NOD.Cg-PrkdcscidIl2rgem1SmocIl15em1(hIL15)Smoc
Strain State:Repository Live | Cat. NO.:GM-NVG-210001
Research Application:Immunotherapy,cancer research,drug screening
Mice
Strain Name:C57BL/6Smoc-Tgtn(pAlb-hAPOB-WPRE-pA)1Smoc
Strain State:Repository Live | Cat. NO.:NM-TG-234136
Mice
Strain Name:C57BL/6Smoc-Tgtn(pAlb-hAPOB-WPRE-pA)1Smoc
Strain State:Developing | Cat. NO.:NM-TG-235092
Mice
Strain Name:NOD-PrkdcscidIl2rgem1Tgtn(pAlb-hHGF-pA)1Smoc
Strain State:Developing | Cat. NO.:NM-TG-234271
Mice
Strain Name:C57BL/6Smoc-Tg(pAlb-hLPA)1Smoc
Strain State:Repository Live | Cat. NO.:NM-TG-225001
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