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Immune Checkpoints

SMOC has developed a set of mouse models expressing humanized immune checkpoints. These models are suitable to assess the efficacy of drugs targeting immune checkpoints in fully immunocompetent mice.

Mice	hPD-1/hCD27(2) Strain Name：C57BL/6Smoc-Pdcd1^em1(hPDCD1)Cd27^{tm2(hCD27)Smoc} Strain State：Embryo cryopreservation \| Cat. NO.：NM-HU-2000096 Research Application：Immunotherapy,cancer research,drug screening
Mice	hPD-1/hCD28 Strain Name：C57BL/6Smoc-Pdcd1^em1(hPDCD1)Cd28^{em2(hCD28)Smoc} Strain State：Embryo cryopreservation \| Cat. NO.：NM-HU-2000097 Research Application：Immunotherapy,cancer research,drug screening
Mice	hPD-1/hCD3E Strain Name：C57BL/6Smoc-Pdcd1^em1(hPDCD1)Cd3e^{em1(hCD3E)Smoc} Strain State：Embryo cryopreservation \| Cat. NO.：NM-HU-18021 Research Application：Immunotherapy,cancer research,drug screening
Mice	hPD-1/hCD40 Strain Name：C57BL/6Smoc-Pdcd1^em1(hPDCD1)Cd40^{em1(hCD40)Smoc} Strain State：Repository Live \| Cat. NO.：NM-HU-190017 Research Application：Immune-related
Mice	hPD-1/hCTLA-4 Strain Name：C57BL/6Smoc-Pdcd1^em1(hPDCD1)Ctla4^{em1(hCTLA4)Smoc} Strain State：Embryo cryopreservation \| Cat. NO.：NM-HU-00079 Research Application：cancer research,Immunotherapy,drug screening
Mice	hPD-1/hCTLA-4(BALB/c) Strain Name：BALB/cAnSmoc-Pdcd1^em1(hPDCD1)Ctla4^{em1(hCTLA4)Smoc} Strain State：Embryo cryopreservation \| Cat. NO.：NM-HU-200277
Mice	hPD-1/hICOS(2) Strain Name：C57BL/6Smoc-Pdcd1^em1(hPDCD1)Icos^{em1(hICOS)Smoc} Strain State：Embryo cryopreservation \| Cat. NO.：NM-HU-2000100 Research Application：Immunotherapy,cancer research,drug screening
Mice	hPD-1/hIL1B Strain Name：C57BL/6Smoc-Pdcd1^em1(hPDCD1)Il1b^{tm3(hIL1B)Smoc} Strain State：Embryo cryopreservation \| Cat. NO.：NM-HU-210018 Research Application：tumor research；inmmue therapy；drug screening
Mice	hPD-1/hLAG3 Strain Name：C57BL/6Smoc-Pdcd1^em1(hPDCD1)Lag3^{em1(hLAG3)Smoc} Strain State：Embryo cryopreservation \| Cat. NO.：NM-HU-00101 Research Application：Immunotherapy,cancer research,drug screening
Mice	hPD-1/hLAG3/hTIGIT Strain Name：C57BL/6Smoc-Pdcd1^em1(hPDCD1)Lag3^em1(hLAG3)Tigit^{em1(hTIGIT)Smoc} Strain State：Embryo cryopreservation \| Cat. NO.：NM-HU-200258 Research Application：tumor research；inmmue therapy；drug screening

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