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U-GEMMs

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Mice

Rag2/IL2rg-KO/hSIRPA(2)/hCD47

Strain Name:C57BL/6Smoc-Sirpaem1(hSIRPA)Cd47em1(hCD47)Rag2em1Il2rgem1/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-2000019

The Rag2 and Il2rg genes of the hSIRPA(2)/hCD47 mouse were deleted.

Mice

Acta2-CreERT2

Strain Name:C57BL/6Smoc-Acta2em1(CreERT2-Wpre-polyA)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-200074

A CreERT2-Wpre-polyA expression cassette was knocked into the Acta2 gene start codon site.

Mice

hTLR8

Strain Name:C57BL/6Smoc-Tlr8tm2(TLR8)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-190044

The endogenous mouse Tlr8 gene was replaced by human TLR8 gene.

Mice

B2m-KO

Strain Name:C57BL/6Smoc-B2mem3Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KO-18021

Exon2-3 of B2m gene were deleted to generate Ifngr1 knockout mice.

Mice

hCRBN

Strain Name:C57BL/6Smoc-Crbntm1(hCRBN)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-225071

The endogenous mouse Crbn gene was replaced by human CRBN gene.

Mice

hCCR8(2)

Strain Name:C57BL/6Smoc-Ccr8em3(hCCR8)/Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-2000054

The endogenous mouse Ccr8 gene was replaced by human CCR8 gene. While hCCR8(Stock No.NM-HU-190053) mice function similarly to hCCR8(2) mice,for more detailed information please contact our technical advisor.

Mice

Drd1-2A-CreERT2

Strain Name:C57BL/6Smoc-Drd1em1(2A-CreERT2-WPRE-pA)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-18016

A 2A-CreERT2-WPRE-pA coexpression cassette is inserted befor the stop codon of mouse Drd1 gene via homologous recombination to establish a tamoxifen inducible Drd1-CreERT2 tool stain. This strain can be used to knockout target gene in Drd1+ cells after tamoxifen treatment when crossed with mice which carry loxp sites flanking target gene.

Mice

hTLR8/Lyz2-DTREGFP

Strain Name:C57BL/6Smoc-Lyz2em3(IRES-DTREGFP)Tlr8tm2(TLR8)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-200259

NM-KI-190041 was crossed with NM-HU-190044 to generate hTLR8/Lyz2-IRES-DTREGFP mice.

Mice

hVISTA

Strain Name:C57BL/6Smoc-Vsirem1(hVSIR)/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-00118

The exon 2-3 of endogenous mouse Vsir gene was replaced by the exon 2-3 of human VSIR(VISTA) gene.

Mice

hPD-L1/hLAG3

Strain Name:C57BL/6Smoc-Cd274em1(hPD-L1)Lag3tm1(hLAG3)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-00137

hPD-L1(NM-HU-00062)was crossed with hLAG3(NM-HU-00049)to generate hPD-L1/hLAG3.

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