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U-GEMMs

About 42,406 results
Mice

R26-CAG-LSL-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-Luciferase-2A-EGFP-wpre-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190095

A CAG-LSL-Luciferase-2A-EGFP-wpre-polyA expression cassette was inserted at the Rosa26 locus site.

Mice

Ins2-CreERT2

Strain Name：C57BL/6Smoc-Ins2em(CreERT2)1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-225022

CreERT2 expression cassette was knocked into the Ins2 gene .

Mice

hCD40L(BALB/c)

Strain Name：BALB/cAnSmoc-Cd40lgtm1(hCD40L)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000052

The endogenous mouse Cd40lg gene was replaced by human CD40L gene.

Mice

MHC Class II(I-A/I-E)-KO(Nod-Scid)

Strain Name：NOD-PrkdcscidH2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-psem1Smoc
Strain State：Developing | Cat. NO.：NM-KO-18057

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the Nod-Scid genetic background and lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

hPD-L1/h4-1BB(2)

Strain Name：C57BL/6Smoc-Cd274em1(hPD-L1)Tnfrsf9tm2(h4-1BB)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200260

hPD-L1(NM-HU-00062) was crossed with h4-1BB(2)(NM-HU-190077) to generate hPD-L1/h4-1BB(2).

Mice

Gli1-CreERT2

Strain Name：C57BL/6Smoc-Gli1em1(CreERT2-Wpre-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200073

A CreERT2-Wpre-polyA expression cassette was knocked into the Gli1 gene start codon site. Gli1 encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. When these Gli1-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Gli1 expressing cells; making them useful for studying axis patterning, proliferation, and cell fate specification of Hedgehog responding cells at different stages of embryogenesis.

Mice

hLILRA4

Strain Name：C57BL/6Smoc-Tgtn(hLILRA4)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-225074

The hLILRA4 expression cassette was knocked into the Chr7 locus.

Mice

Ids-KO

Strain Name：C57BL/6Smoc-Idsem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-200580

Exon 2 of Ids gene was deleted to generate Ids knockout mice.

Mice

Txlna-Luc-EGFP

Strain Name：C57BL/6Smoc-Txlnaem1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00026

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Txlna.

Mice

Ins2-C96Y

Strain Name：C57BL/6Smoc-Ins2em3(C96Y)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190096

These mice carry a p.C96Y mutation of Ins2 gene.

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