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U-GEMMs

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Mice

Zbtb46-IRES-Cre

Strain Name：C57BL/6Smoc-Zbtb46em1(IRES-iCre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200096

A IRES-iCre expression cassette was knocked into the Zbtb46 gene stop codon site.

Mice

C9orf72-KO

Strain Name：C57BL/6Smoc-C9orf72em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-201246

Exon 4-5 of C9orf72 gene was deleted to generate C9orf72 knockout mice.

Mice

Erbb2-Flox

Strain Name：C57BL/6Smoc-Erbb2em(flox)/Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-220557

These mice carry loxP sites flanking exon 2 of Erbb2 When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Erbb2 gene.

Mice

hSIGLEC9

Strain Name：C57BL/6Smoc-Sigleceem1(hSIGLEC9)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-225072

The endogenous mouse Siglece gene was replaced by human SIGLEC9 gene.

Mice

Postn-2A-Cre

Strain Name：C57BL/6Smoc-Postnem(2A-Cre)1Smoc
Strain State：Developing | Cat. NO.：NM-KI-225034

2A-Cre expression cassette was knocked into the Postn gene .

Mice

hIL11/hIL11RA

Strain Name：C57BL/6Smoc-Il11em1(hIL11)Il11ra1tm1(hIL11RA)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210372

hIL11(NM-HU-204981) was crossed with hIL11RA (NM-HU-204982) to generate hIL11/hIL11RA mice.

Mice

Tmem119-2A-CreERT2

Strain Name：C57BL/6Smoc-Tmem119em2(P2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200234

A P2A-CreERT2 expression cassette was knocked into the Tmem119 gene stop codon site.

Mice

R26-Renilla-Luc

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-LSL-Renilla-Luc)-NSmoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00091

These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Renilla-Luc gene. The targeted mutation was inserted into the Gt(ROSA)26Sor locus by homologous recombination.

Mice

hPD-1/hPD-L1/hTIM3

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Havcr2em1(hHAVCR2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200264

hTIM3（NM-HU-00054）,hPD-1（NM-HU-00015）,hPD-L1（NM-HU-00062）were crossed together to generate hPD-1/hPD-L1/hTIM3 mice

Mice

R26-pVillin1-hCYP3A4-IRES-tdTomato(FVB)

Strain Name：FVB-Gt(ROSA)26Sorem1(Gut-CYP3A4-IRES-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18033

Intestinal expression of the CYP3A enzyme in the human body can cause significant intestinal metabolism of the compound, resulting in impaired drug absorption. This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the Villin1 promoter together with the IRES-tdTomato reporter gene into mosue Rosa26 site, which can be crossed with the Cyp3a13 gene knockout and other Cyp3a family genes knockout mice to obtain intestinal-expressed CYP3A4 humanized mouse model in order to determine the contribution of intestinal metabolism to the absorption and distribution of test article.

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