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U-GEMMs

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Mice

Muc2-2A-CreERT2-IRES-tdTomato

Strain Name：C57BL/6Smoc-Muc2em1(2A-CreERT2-tdTomato-Wpre-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200301

2A-CreERT2-tdTomato-Wpre-pA expression cassette was knocked into the Muc2 gene stop codon site.

Mice

Ace2-2A-CreERT2

Strain Name：C57BL/6Smoc-Ace2em2(2A-CreERT2-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200187

A 2A-CreERT2-WPRE-polyA expression cassette was knocked into the Ace2 gene stop codon site. Ace2 encodes angiotensin I converting enzyme 2. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Cre. This strain is useful for studying lung injury and kidney disease caused by SARS coronavirus infection.

Mice

hTLR7

Strain Name：C57BL/6Smoc-Tlr7tm1(hTLR7)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18027

The endogenous mouse Tlr7 gene was replaced by humanTLR7  gene.

Mice

Rag2/IL2rg-KO/hCD40

Strain Name：C57BL/6Smoc-Cd40em1(hCD40)Rag2em1Il2rgem1/Smoc
Strain State：Developing | Cat. NO.：NM-HU-2000112

The Rag2 and Il2rg genes of the CD40 humanized mouse were deleted.

Mice

hC1QA

Strain Name：C57BL/6Smoc-C1qaem1(hC1QA)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200282

The endogenous mice C1qa gene was replaced by human C1QA gene.

Mice

hC3

Strain Name：C57BL/6Smoc-C3em1(hC3)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000079

The endogenous mouse C3 gene was replaced by human C3 gene.

Mice

hCD38(2)

Strain Name：C57BL/6Smoc-Cd38em2(CD38)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190059

The endogenous mouse Cd38 gene was replaced by human CD38 gene. While hCD38 mice(Stock No.NM-HU-00113）have been pulled from shelves for some reasons.

Mice

hTLR9

Strain Name：C57BL/6Smoc-Tlr9tm1(hTLR9)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18016

This TLR9 humanized mouse model was established by replacing the mouse Tlr9 gene exon2 with the human TLR9 corresponding sequence by homologous recombination.

Mice

hOCLN

Strain Name：C57BL/6Smoc-Oclnem1(hOCLN)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190072

The endogenous mouse Ocln gene was replaced by human OCLN gene.

Mice

H11-CAG-LSL-mtagBFP2

Strain Name：C57BL/6Smoc-lgs2em1(CAG-LSL-mTagBFP2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190006

A CAG-LSL-mTagBFP2-3xFLAG-WPRE-polyA cassette was inserted at the mouse H11 locus. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the mTagBFP2-3xFLAG protein.

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