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U-GEMMs

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Mice

Rag2-KO

Strain Name：C57BL/6Smoc-Rag2em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190429

Partial exon 3 of Rag2 gene was deleted to generate Rag2 knockout mice. Deletion of this region will cause frameshift and result in loss of function of mouse Rag2 gene.

Mice

hVSIG4

Strain Name：C57BL/6Smoc-Vsig4em1(hVSIG4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210004

The endogenous mice Vsig4 gene was replaced by human VSIG4 gene

Mice

hABCC2

Strain Name：C57BL/6Smoc-Abcc2tm1(hABCC2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200254

The endogenous mice Abcc2 gene was replaced by human ABCC2 gene.

Mice

hCCL1

Strain Name：C57BL/6Smoc-Ccl1em2(hCCL1)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000074

The endogenous mouse Ccl1 gene was replaced by human CCL1 gene.

Mice

h4-1BB(2)/hOX40

Strain Name：C57BL/6Smoc-Tnfrsf9tm2(TNFRSF9)Tnfrsf4em1(hTNFRSF4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200272

hTNFRSF9(NM-HU-190077) was crossed with hOX40(NM-HU-00041)to generate h4-1BB(2)/hOX40 mice

Mice

hIL12B

Strain Name：C57BL/6Smoc-Il12betm3(hIL12B)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000057

The endogenous mouse Il12b gene was replaced by human IL12B gene.

Mice

Hopx-2A-DreERT2

Strain Name：C57BL/6Smoc-Hopxem1(2A-DreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190035

A 2A-DreERT2 expression cassette was knocked into the Hopx gene stop codon site.

Mice

hCTLA-4

Strain Name：C57BL/6Smoc-Ctla4em1(hCTLA4) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00014

The endogenous mouse Ctal4 gene was replaced by human CTLA4 gene. While hCTLA4(2)(Stock No.NM-HU-190038) mice function similarly to hCTLA4 mice,for more detailed information please contact our technical advisor.

Mice

G6pc-Flox

Strain Name：C57BL/6Smoc-G6pcem1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200053

These mice carry loxP sites flanking exon 3 of G6pc gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of G6pc gene.

Mice

Rag2-KO(Rag2-EGFP)

Strain Name：B6;129S-Rag2tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00070

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

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